DCX (DDB1-CUL4-X-box) E3 protein ligase complex: A Potential Drug Target and Biomarker
DCX (DDB1-CUL4-X-box) E3 protein ligase complex: A Potential Drug Target and Biomarker
The DCX (DDB1-CUL4-X-box) E3 protein ligase complex is a protein-protein interaction (PPI) that plays a crucial role in the regulation of cell proliferation, differentiation, and survival. The DCX E3 protein ligase complex is composed of the protein DCX, Cul4, and X-box, which are essential for its function. This protein complex is named after its subunits, which are named after the amino acid residues that are involved in the ligase activity of the protein.
The DCX E3 protein ligase complex is a well-established player in various cellular processes, including cell growth, differentiation, and response to stimuli. It plays a key role in the regulation of cell proliferation by activating the G1-to-G2 checkpoint, which is a critical step in the cell cycle. The G1-to-G2 checkpoint is a critical regulatory checkpoint that ensures that cells enter the G2 phase of the cell cycle before proceeding with cell division. The DCX E3 protein ligase complex plays a crucial role in regulating the G1-to-G2 checkpoint by activating the kinase activity of Cul4.
The DCX E3 protein ligase complex is also involved in the regulation of cell differentiation and plasticity. It plays a key role in the regulation of cell fate, including the determination of stem cell and progenitor cell states. The DCX E3 protein ligase complex is also involved in the regulation of cell survival, as it plays a role in the regulation of apoptosis.
In addition to its role in cell proliferation and differentiation, the DCX E3 protein ligase complex is also involved in the regulation of cellular signaling pathways. It plays a key role in the regulation of the PI3K/Akt signaling pathway, which is involved in the regulation of cell survival and survival signaling pathways.
The DCX E3 protein ligase complex is also a potential drug target and biomarker. The over-expression of the DCX gene has been shown to inhibit the growth of cancer cells, and it is suggested as a potential biomarker for cancer diagnosis and treatment. Additionally, the DCX E3 protein ligase complex is also a target for small molecules, and several compounds have been shown to interact with this protein complex and modulate its function.
Conclusion
The DCX (DDB1-CUL4-X-box) E3 protein ligase complex is a crucial player in the regulation of cell proliferation, differentiation, and survival. It plays a key role in the regulation of the G1-to-G2 checkpoint, cell fate, and apoptosis. The DCX E3 protein ligase complex is also involved in the regulation of cellular signaling pathways, including the PI3K/Akt signaling pathway.
The DCX E3 protein ligase complex is a potential drug target and biomarker. The over-expression of the DCX gene has been shown to inhibit the growth of cancer cells, and it is suggested as a potential biomarker for cancer diagnosis and treatment. Additionally, the DCX E3 protein ligase complex is also a target for small molecules, and several compounds have been shown to interact with this protein complex and modulate its function. Further studies are needed to fully understand the role of the DCX E3 protein ligase complex in cellular processes and its potential as a drug target and biomarker.
Protein Name: DCX (DDB1-CUL4-X-box) E3 Protein Ligase Complex
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More Common Targets
DCX DET1-COP1 ubiquitin ligase complex | DCX(DCAF15) E3 protein ligase complex | DCXR | DDA1 | DDAH1 | DDAH2 | DDB1 | DDB2 | DDC | DDC-AS1 | DDD core complex | DDHD1 | DDHD2 | DDI1 | DDI2 | DDIAS | DDIT3 | DDIT4 | DDIT4L | DDN | DDO | DDOST | DDR1 | DDR2 | DDRGK1 | DDT | DDTL | DDX1 | DDX10 | DDX11 | DDX11-AS1 | DDX11L1 | DDX11L10 | DDX11L2 | DDX11L8 | DDX11L9 | DDX12P | DDX17 | DDX18 | DDX18P1 | DDX19A | DDX19A-DT | DDX19B | DDX20 | DDX21 | DDX23 | DDX24 | DDX25 | DDX27 | DDX28 | DDX31 | DDX39A | DDX39B | DDX39B-AS1 | DDX3P1 | DDX3X | DDX3Y | DDX4 | DDX41 | DDX42 | DDX43 | DDX46 | DDX47 | DDX49 | DDX5 | DDX50 | DDX50P1 | DDX51 | DDX52 | DDX53 | DDX54 | DDX55 | DDX56 | DDX59 | DDX59-AS1 | DDX6 | DDX60 | DDX60L | DDX6P1 | DEAF1 | Death-associated protein kinase | Decapping Complex | DECR1 | DECR2 | DEDD | DEDD2 | Dedicator of cytokinesis protein | DEF6 | DEF8 | DEFA1 | DEFA10P | DEFA11P | DEFA1B | DEFA3 | DEFA4 | DEFA5 | DEFA6 | DEFA7P | DEFA8P | DEFA9P
